Matthew 10:33 means that if someone publicly rejects or disowns Jesus in front of others, Jesus will also disown that person before God the Father in heaven. This verse highlights the seriousness of acknowledging or denying Jesus in one's life, especially in the presence of others.
In this verse, Jesus is speaking to His disciples as He prepares them to go out and share His message. He warns them about the challenges and opposition they might face, making it clear that their response to Him—whether they stand with Him or deny Him—has eternal significance. The verse is part of a larger passage where Jesus talks about loyalty, courage, and the cost of following Him.